Hi Simon from Steve Smith at Pico Technology. Sorry you are having these issues, can you confirm that the issue surrounds entering vehicle details from the EDIT menu or using the FILE-SAVE feature.
I have just tried a similar scenario using a dummy waveform and all entered OK. I have used 22.214.171.124, on Windows 8 is this the same software you have?
Could I ask if all your Windows Vista updates are up to date?
Do you have more than one version of Picoscope stored on your PC?
I am sorry if this sounds like 20 questions but it will help to assist.